Carlton skipper Marc Murphy is in danger of missing the rest of the AFL season due to an ankle injury he suffered in round 10.Murphy was expected to miss about three weeks after suffering the high ankle sprain in the Blues upset win over Geelong, but he continues to be hampered by the problem.He wont play against Brisbane on Saturday and, with just two games remaining after that, hes running out of time to feature again this season.Ive tried to do everything I can to get back playing, but it hasnt allowed me to unfortunately, Murphy told RSN927 on Wednesday.In terms of trying to get back next week or the week after Im still trying to push for that but whether or not it pulls up well enough and I get through remains to be seen.Carlton coach Brendon Bolton remains hopeful Murphy will return before the end of the season, and says its been a frustrating period for his captain.Were really hopeful but the syndesmosis (ankle) injury is one thats really niggling, Bolton told reporters on Wednesday.Its been a little frustrating because its hard to put a timeline on it ... its just how its responding from week to week.But Murph is starting to train with the group now, so were hopeful that before the end of the year he plays.Bolton said no thought had yet been given to ruling out the 29-year-old for the rest of this campaign to allow him to return to full health with an eye on pre-season training.Murphys time on the sidelines has coincided with a downturn in fortunes for the Blues, who will be attempting to snap an eight-game losing streak when they take on the Lions at the Gabba.Weve been in games and against quality opposition weve just lacked some polish to be able to finish, Bolton said.Theres constant commentary about it ... were developing and between now and the end of the year we want to keep evolving.Over pre-season we need to evolve so that were not only a team that gives effort but we can hurt (teams) on turnover. 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When Matchroom Boxing promoter Eddie Hearn announced on Friday that welterweight titleholder Kell Brook would move up two weight classes to challenge the fearsome Gennady Golovkin for his middleweight belts, he also promised to give fans a packed show with multiple world-title fights and some of the biggest names in British boxing.Hearn began to deliver on Monday, announcing that flyweight world titleholder Johnriel Casimero will defend his belt against Charlie Edwards on the card, which will take place Sept. 10 (HBO in the United States, Sky Box Office in the United Kingdom) at the O2 Arena in London.A former junior flyweight world titleholder, Casimero (22-3, 14 KOs), 26, of the Philippines, moved up in weight and traveled to Thailand to challenge Amnat Ruenroeng, who beat him by unanimous decision 13 months ago.?They met in a rematch on May 25 in China and Casimero knocked out Ruenroeng in the fourth round to claim the 112-pound belt. Casimero will be making his first title defense against Englands Edwards, 23, who is inexperienced as a professional but was one of the Great Britains top recent amateurs.Edwards (7-0, 3 KOs) turned pro in January 2015 and will be taking a tremendous step up in class of opponent.Many people may think this is too early, but believe me when I say this: That IBF world title iss coming home with me, Edwards said.ddddddddddddPeople underestimate my engine. Halfway through the fight, when hes behind, he will not be catching up. I didnt turn pro to knock over journeymen. Im in this game to take over the lighter weight divisions. The team behind me know I am more than ready for this and I would like to thank them, Eddie and Barry Hearn for giving me this chance. I wont let anybody down.In a tuneup fight for his title shot, Edwards will be in action on Saturday in Berlin, where he will face Jose Aguilar (16-25-4, 6 KOs), 31, of Spain, in a scheduled six-round bout on the undercard of super middleweight titlist Giovanni De Carolis defense against Tyron Zeuge.This is a huge gamble for Charlie at this stage in his career, but him and the team feel very confident they can beat Casimero, Eddie Hearn said. At flyweight, there is only so much experience you can gain, and this is a huge opportunity for him to become world champion on home soil in what will be just his ninth fight.Sept. 10 is the biggest night in world boxing so far in 2016, and Im delighted to provide this opportunity for Charlie. I believe Britain will have yet another world champion that night. ' ' '